Amended Bitter Orange - Ephedra in Disguise? So Why Do People Still Take It ?

If you read my last article about bitter orange, it was pretty clear how I felt about the herb. I'd read the available research concerning bitter orange, and while there was some evidence supporting bitter orange, the overall picture did not look good.

So that's the picture I painted, however, there were some facts that I was unaware of at the time, which I felt you might be interested in if you're researching bitter orange.

In order to lay these out, I want to answer four questions:

1. What Is Bitter Orange Really ?

2. So does Bitter Orange act similarly to ephedrine ?

3. What about the reports of adverse ill effects of bitter orange ?

4. Is bitter orange safe to use and does it work ?

It's a bit long, but what the heck !

What Is Bitter Orange Really ?:

The Bitter Orange extract found in popular fat burners, is made from the unripe fruit of the citrus aurantium tree. The fruit is picked when they are a dark green in color, halved, dried and then milled into a powder. This makes the herb Zhi Shi1. Bitter orange is the western name for Zhi Shi.

The bitter orange herb contains five alkaloids (see alkaloid definition5), the most dominant of which is Synephrine (the compound I referred to in my last article), structurally similar to ephedrine. However, while they are similar, they're not the same.

Both synephrine and ephedrine stimulate the sympathetic nervous system and at a cellular level, affect alpha cell receptors, and to a lesser extent, beta cell receptors6. Ephedrine will affect beta(1), beta(2) and beta(3) cell receptors, however, of the beta-cell receptors, synephrine appears to only affect beta(3) cells, those believed to be responsible for thermogenesis or fat burning affects7. Beta(1) and beta(2) receptors are believed to be responsible for cardiac and pulmonary functions.

So does Bitter Orange act similarly to ephedrine ?

Does it ? While previously, I've presented a very black and white view of whether it acts similarly to ephedrine, I am now not so sure.

There is some confusion as to how synephrine affects heart rates and blood pressure. Intravenously injected synephrine will cause increased heart rates and blood pressure, however, orally taken synephrine does not, and synephrine contained in most herbal weight loss supplements are taken orally.

Generally speaking because synephrine stimulates beta(3) cells but not beta(2) and beta(1) cells, it can provide the thermogenic effects without the undesirable cardiac side effects that ephedrine did.

What about the reports of adverse ill effects of bitter orange ?

The American Herbal Products Association has found that there were errors in the reported adverse event reports attributed to the use of bitter orange in September 20043. The association found that numbers reported in the media were in fact duplicates for adverse event reports for ephedrine, and when all was said and done, there was really only one report of an adverse reaction attributed to a bitter orange supplement, where no other ingredient was included in the supplement. In this particular case, it involved a 74 year old woman had been taking prescription medication and two other herbal preparations simultaneously. This one case occurred more than five years ago3.

What about the 55 year old woman reported by Nykamp DL, Fackih MN, Compton AL (2004), who experienced chest pain after consuming a supplement containing bitter orange. Researchers in this case study had commented "Based on the Naranjo probability scale, C. aurantium is possibly associated with this cardiovascular event"4, however, as bitter orange was not the only ingredient in the supplement, it cannot be known whether in this case, that bitter orange was the herb responsible.

Is bitter orange safe to use and does it work ?

Now there are many others, who felt as I did, that bitter orange is another Ephedra waiting to happen, and will have the same consequences. However, when bitter orange is taken in isolation, it does not have adverse side effects.

In fact, when it is combined with other selected herbs, it may have benefits for health and weight loss. Research performed with 20 individuals over six weeks found no adverse reactions occurred when citrus aurantium was combined with caffeine and St. Johns Wort2. They also found that the individuals who were given the supplement (group A) lost an average of 2.9% body fat. "In terms of actual fat loss, group A lost a significant amount (3.1 kg), whereas the control group demonstrated a tendency toward fat loss." So, this study has demonstrated that there are weight loss benefits involved here, but also the control group who received nothing exhibited a tendency towards fat loss, suggesting that if the study had been extended beyond 6 weeks, the control group would have lost body fat as well.

Conclusions:

2004 was not a great year for bitter orange in the media. It has successfully battled reports of adverse events alleged to be a result of consuming bitter orange. These numbers proved to be incorrect.

While synephrine the main alkaloid of bitter orange, is chemically similar to ephedrine, it is not the same as ephedrine and differs in the way it reacts pharmacologically within the human body.

Although at first look at the research, bitter orange presented with dangers that I wanted to warn against, a more in-depth look has revealed that bitter orange by itself is not dangerous. The citrus aurantium extract standardized for synephrine (3-6%) is accepted as safe7.

But hang on, before you click off this page, to go and find a fat burner with citrus aurantium in it, I do also want to say, that they can't be used as an alternative to good food and exercise.

Herbal supplements such as those containing bitter orange can be helpful but only when used within a weight loss strategy of balanced eating and exercise, and while they may benefit some, it may not benefit others and only your doctor will be able to make that decision for you6. The results may be slower, but a balanced diet and exercise are the keys to permanent and healthy weight loss. So while bitter orange may be helpful, you can obtain the same results without it. What-ever stage you are at with your health and fitness, diet and exercise are the two most important aspects.

If you do decide you'd like to try a supplement containing bitter orange, please consult your doctor before purchasing a bitter orange product.

Essentially if you consult your doctor about bitter orange, as we say in Australia - you can't go wrong, mate. Your doctor will be able to refer you to your nearest dietician and will recommend the best weight loss strategy for your situation.

References:

1. Jones, D., "Bitter Orange or Citrus Aurantium: same difference ?"

2. Colker et. al., (1999) Effects of Citrus Aurantium extract, caffeine, and St. John's Work on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr. Ther. Res. 60, 145 ? 153.

3. american herbal products (2004) "fda spins numbers on bitter orange aers" press release

4. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother. 2004 May;38(5):812-6. Epub 2004 Mar 16.

5. american herbal products (2004) "fda spins numbers on bitter orange aers" press release - any of hundreds of compounds found in plants with a nitrogen atom connected to two carbon atoms, and often formed in a ring structure. Many commonly known chemicals and drugs are alkaloids, including nicotine, cocaine, quinine, morphine, and ephedrine.

6. Dharmananda, S., american herbal products (2004) "fda spins numbers on bitter orange aers" press release Institute for Traditional Medicine, Portland, Oregon. See the schematic diagram for synephrine at the bottom of the page.

7. american herbal products (2004) "fda spins numbers on bitter orange aers" press release

Other Sites of Interest:

american herbal products (2004) "fda spins numbers on bitter orange aers" press release

About The Author

Copyright ? 2004 Jenny Mathers All Rights Reserved.

Research resource for american herbal products (2004) "fda spins numbers on bitter orange aers" press release. Fat burning food research information allowing you to take the guess work out of fat burning.

same day cleaning service Des Plaines ..

---

Vitamin B-2

Riboflavin is a common name for vitamin B-2 and was... Read More

Anabolic Steroids and Will They Work for Me?

Unfortunately nobody can tell that question over the internet, but... Read More

Should You Take Gingko Biloba to Improve Your Brain Power?

Have you heard of the herbal supplement with the very... Read More

Nutritional Supplement

Nutritional Supplement ? what is it?So what is a nutritional... Read More

Vitamin Euphoria ? A Shot in the Dark

Vitamins seem to be so good for everything. The newly... Read More

The Effects of an no2 Supplement on Your Body

Our system uses a free-form gas called Nitric Oxide as... Read More

Omega 3 and Reduced Risk of Myocardial Infarction

Myocardial infarction is a technical term used to describe an... Read More

The Secrets of Looking and Feeling Younger and HGH Supplements

The mankind has never stopped searching for the scerets of... Read More

Vitamin Supplements in a Liquid World

Every day, it seems like we are living in an... Read More

L-Glutathione, The Wonder Antioxidant

A naturally occurring compound, L-Glutathione (Tathion,) has demonstrated that it... Read More

Increasing overall Health with Nutritional Supplements

"But I eat healthy," you might say. That may be... Read More

Congestive Heart Failure And CoQ10

Since the 1960???s there have been numerous controlled clinical trials... Read More

Using Natural Remedies For Constipation

There are two basic types of constipation - organic and... Read More

Finding Fish

Fetuses and infants simply must get enough omega-3 oils for... Read More

Vitamins: How To Keep Your Body Healthy By Using Vitamins Safely

Vitamins are an important part of a health diet. Unlike... Read More

Probiotics and Friendly Flora

You Need Probiotics For Better Digestion and Overall HealthInside your... Read More

Shopping for Supplements -- Living Healthy and Saving Money

When it comes to personalized weight loss programs and their... Read More

Nutritional Nutrients

Nutrients form the basis for your body, emotional and spiritual... Read More

Know Your Bodybuilding Supplement - NO Nitric Oxide

Nitric oxide is a free form gas produced by the... Read More

Side Effects of Hyaluronic Acid Products

Currently, there are no known side effects for most hyaluronic... Read More

Supplements and Vitamins - Can They Enhance Your Weight Loss Goals?

Nutritional supplements can play a key role in the health... Read More

Coral Calcium: The Preferred Source of Absorbable Calcium

Coral Calcium is an excellent source of readily accessible and... Read More

Vitamin - Essential Nutrients for Health

Vitamins are the stars of the nutrition scene. Nutrition, the... Read More

Kanhaiya Amla Powder

AMLA ( EMBLICA OFFICINALIS ) FOR HEALTH AND BEAUTYAMLA, proudly... Read More

Is Lunesta Safe For You?

Everyone has an occasional sleepless night, and this is not... Read More

home cleaning services Mundelein ..