Home
>
Weight Loss
>
Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin and yang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of either too hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulin and you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are too thin, emaciated and weak.

As we have mentioned previously, when man evolved there would be times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famine by using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largest amount of available energy in an average 70 kilogram human is overwhelmingly stored in -fat. For the purpose of this discussion let's think of each of these numbers above as fuel tanks, for our energy needs. When we fill up our cars with gasoline (our old Mercedes B100 biodiesel) we have to have a fuel hose to get the fuel into our gas tank. In order to use that fuel in our gas tanks, we have to have a fuel line leading from the gas tank to the motor in our car. Without these fuel lines, we could not utilize our engine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems. One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate. As with any biochemical reaction that is dependant on an enzyme system, the more it is used, the more developed it becomes. If there is no need for an enzyme, then the levels in the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meet the demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storage tanks, especially the largest energy storage tank fat, is insulin. Insulin is the hose that energy (gasoline, biodiesel) flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use. Without this fuel line insulin, you will eventually go into a coma (hyperosmolar) that if not treated, can result in less than optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fuel tanks. In order for us to use that fuel, it must get from the storage tank to the motor. In the human, that fuel line is glucagon. Remember, insulin stores energy, glucagon utilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagon stimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures that did not have consistent daily feedings to our "modern" fast food insanity and the notion that now we need three "square" meals a day plus snacks. What happens to our energy metabolism when we start out putting insulin stimulating foods in our stomach three times a day? When we eat, our biochemistry reacts by secreting insulin, so that we can store all this energy for future needs -most of it going into fat. Long before we have used any of this energy, we are having another meal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in. We spend our whole day and most of the night in a "fed" or insulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enough so that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly with gas. There is hardly any room for a driver in the front seat. Huge fuel tanks full of fat are everywhere we look. Your car is loaded with gas, but you can't drive around the block because you haven't developed the enzymes of energy utilization to establish a fuel line between all these gas tanks full of fat and our motor, which is now also encased in fat. While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Without proper stimulation of the glucagon system, our tanks just keep filling up with fat. We never develop the necessary enzymes to use all this energy. You don't have to travel too far to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't know how many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done, you don't get lethargic after eating and you start to actually feel thin. I don't recommend fasting more than 24 hours and I am not actually recommending a 24 hour fast. What I am recommending is that during some portion of every day or at least every other day, you refrain from eating anything so that you can get into a glucagon state and begin to induce the necessary enzymes to use all the energy the human body can store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.drmericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.

cheap limo service Lombard .. Lockport Chicago limo O’Hare

In The News:

Recent reports show many common passwords can be cracked in literally seconds. Kurt the CyberGuy explains how to strengthen your passwords.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Iron, a robot that stands 5 feet, 8 inches tall and weighs 154 pounds, combines advanced artificial intelligence with human-like movement and exceptional vision.

Hertz, the rental car giant, recently confirmed that customer information was exposed through a cyberattack on one of its software vendors.

There are a number of features with AirPods you may or may not know about to take your listening experience to the next level. Kurt the CyberGuy explains.

These 35 Chrome extensions have privacy and security concerns. Tech expert Kurt “CyberGuy" Knutsson says to delete them now.

Tech expert Kurt “CyberGuy" Knutsson says 329,000 mph fusion rocket promises to be fast, disruptive and enable deep-space missions.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Tech expert Kurt “CyberGuy" Knutsson says a new autonomous AI is a game changer that also raises privacy risks. Is your data safe?

Tech expert Kurt “CyberGuy" Knutsson says robots and drones are revolutionizing fruit farming with faster picking and smarter handling.

Landmark Admin revises May 2024 cyberattack scope to show twice as many people were affected. Kurt “CyberGuy" Knutsson gives tips to help stay safe from an insurance data breach.

Tech expert Kurt “CyberGuy" Knutsson talks about how Yamaha’s hydrogen outboard motor could revolutionize boating with zero emissions.

Tech expert Kurt “CyberGuy" Knutsson reveals how to memorialize or remove a deceased loved one’s Facebook account and protect their digital legacy from misuse or scams.

Tech expert Kurt “CyberGuy" Knutsson says an Apple Watch saved psychiatrist Amanda Faulkner by detecting deadly leukemia early.

Scammers and fraudsters are increasingly targeting the most vulnerable, especially nursing homes and the personal data of their residents. Kurt the CyberGuy has safety tips.

Infected USB flash drives can spread malware among multiple organizations in ways that can easily bypass traditional security systems.

With a fully automated warehouse system and AI-powered robots, Ocado's Hive picks, packs and delivers grocery store orders in just a few minutes.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Recycling robots are using artificial intelligence to learn how to sort recyclables by recognizing patterns in colors, textures, shapes and logos.

The Reachy 2 robot is designed to be friendly and approachable, inviting natural interaction and is perfect for research, education and experimenting with embodied AI.

Kurt "CyberGuy" Knutsson shares several easy ways to keep your credit cards safe from digital thieves while you're traveling this summer.

Arcturus sets up cameras around the edges of baseball stadiums to capture real-time action and generate a 3D digital clone of the game.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

The CyberGuy explains why healthcare organizations are vulnerable to hackers after there have been a half dozen data breaches this year.

Developed at two California universities, the innovative technology combines brain-computer interfaces with advanced AI to decode neural activity into audible speech.