Home
>
Weight Loss
>
Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin and yang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of either too hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulin and you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are too thin, emaciated and weak.

As we have mentioned previously, when man evolved there would be times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famine by using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largest amount of available energy in an average 70 kilogram human is overwhelmingly stored in -fat. For the purpose of this discussion let's think of each of these numbers above as fuel tanks, for our energy needs. When we fill up our cars with gasoline (our old Mercedes B100 biodiesel) we have to have a fuel hose to get the fuel into our gas tank. In order to use that fuel in our gas tanks, we have to have a fuel line leading from the gas tank to the motor in our car. Without these fuel lines, we could not utilize our engine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems. One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate. As with any biochemical reaction that is dependant on an enzyme system, the more it is used, the more developed it becomes. If there is no need for an enzyme, then the levels in the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meet the demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storage tanks, especially the largest energy storage tank fat, is insulin. Insulin is the hose that energy (gasoline, biodiesel) flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use. Without this fuel line insulin, you will eventually go into a coma (hyperosmolar) that if not treated, can result in less than optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fuel tanks. In order for us to use that fuel, it must get from the storage tank to the motor. In the human, that fuel line is glucagon. Remember, insulin stores energy, glucagon utilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagon stimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures that did not have consistent daily feedings to our "modern" fast food insanity and the notion that now we need three "square" meals a day plus snacks. What happens to our energy metabolism when we start out putting insulin stimulating foods in our stomach three times a day? When we eat, our biochemistry reacts by secreting insulin, so that we can store all this energy for future needs -most of it going into fat. Long before we have used any of this energy, we are having another meal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in. We spend our whole day and most of the night in a "fed" or insulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enough so that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly with gas. There is hardly any room for a driver in the front seat. Huge fuel tanks full of fat are everywhere we look. Your car is loaded with gas, but you can't drive around the block because you haven't developed the enzymes of energy utilization to establish a fuel line between all these gas tanks full of fat and our motor, which is now also encased in fat. While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Without proper stimulation of the glucagon system, our tanks just keep filling up with fat. We never develop the necessary enzymes to use all this energy. You don't have to travel too far to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't know how many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done, you don't get lethargic after eating and you start to actually feel thin. I don't recommend fasting more than 24 hours and I am not actually recommending a 24 hour fast. What I am recommending is that during some portion of every day or at least every other day, you refrain from eating anything so that you can get into a glucagon state and begin to induce the necessary enzymes to use all the energy the human body can store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.drmericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.

quick home cleaning Glenview ..

In The News:

Instagram's new 'Your Algorithm' tool lets you control your Reels feed in real time. The app now gives you power to customize what videos you see.

Major Marquis fintech breach exposes 400,000-plus Americans' data through unpatched SonicWall vulnerability, with Texas hardest hit at 354,000 affected.

Free up iPhone storage fast by clearing large photos and videos from Messages app. Simple steps for iOS users to delete attachments without losing chats.

Scammers are flooding inboxes with fake tracking alerts that mimic real carriers, exploiting the holiday rush to steal logins and personal data.

The Fox News AI Newsletter brings you the latest news on AI technology advancements and the challenges and opportunities AI presents now and for the future.

Texas family reunites with missing 11-year-old cat Grayson after 103 days using Petco Love Lost's AI photo matching technology and community help.

Tired of AI customer service loops? These insider tricks help you escape "frustration AI" and get real human help when you need it most for urgent issues.

Unlock richer audio from your streaming apps with simple tweaks to volume normalization, equalizer settings, and quality preferences for cleaner sound.

Scammers are sending fake Facebook settlement payout emails that mimic legitimate notices from the privacy settlement administrator to deceive users.

Holiday shopping scams surge as fake refund emails target distracted consumers during Black Friday and holiday seasons, costing Americans billions annually.

The AI-powered IRMO M1 exoskeleton features four modes, including turbo, eco, training and rest for hiking, running, cycling and sports with eight-hour battery life.

OpenAI announced upgrades for its ChatGPT Images platform on Tuesday, saying the program can now make more precise edits and produce images more quickly.

Chrome for Android now turns web articles into AI-powered podcast conversations. Get hands-free browsing with Google Gemini's natural audio summaries.

LastPass faces $1.6 million fine from U.K. regulators after 2022 data breach exposed 1.6 million users. Password manager failed proper security controls.

Petco disclosed a data breach exposing customer Social Security numbers, financial account details, and driver's license information due to a software error.

Baseball teams can now analyze complete swing mechanics in normal training environments using Theia's markerless AI system that processes standard high-speed footage.

Smart home hacking fears overblown? Expert reveals real cybersecurity risks and simple protection tips to keep your connected devices safe from hackers.

MIT develops needle-free glucose monitor using light technology. Revolutionary device could replace painful finger pricks for diabetes management.

The ClickFix campaign disguises malware as legitimate Windows updates, using steganography to hide shellcode in PNG files and bypass security detection systems.

Researchers from Osaka Metropolitan University designed a 21-foot dome that combines aquaculture and hydroponics to create a self-sustaining urban food system.

The Fox News AI Newsletter gives readers the latest AI technology advancements, covering the challenges and opportunities AI presents.

ChatGPT data breach exposes personal info of users through partner Mixpanel. OpenAI confirms names, emails compromised in security incident.

Android rolls out Emergency Live Video for 911 calls, letting dispatchers see real-time scenes during emergencies. Great for holiday travel safety.

Malicious Chrome and Edge extensions collected browsing history, keystrokes and personal data from millions of users before Google and Microsoft removed them.

Google's new Call Reason feature lets Android users mark calls as urgent before dialing, displaying an urgent label to recipients using Phone by Google app.