Home
>
Weight Loss
>
Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Safe and Permanent Weight Loss Cannot Be Achieved in the Fed State

Weight Loss Axiom Number Three

Insulin and Glucagon

These are the two major hormones that control energy metabolism in the human. They are much like yin and yang, hot and cold or happy and sad. In order to really enjoy the good days, we all have bad days. Extremes of either too hot or too cold and soon everyone complains about the weather. Too much yin or too much yang and according to traditional Chinese Medicine, you are sick. Too much insulin and you are sick, hypertension, overweight, cancer, heart disease and stroke. Too much glucagon and you are too thin, emaciated and weak.

As we have mentioned previously, when man evolved there would be times of famine, between times of feast. The biochemistry of this evolution allowed man to survive the periods of famine by using insulin to "store" energy. Some typical "fuel" reserves in a 70 kilogram man:

Organ ***************** Available energy (kcal)
************ glucose/glycogen ***** fat ***** protein
blood *********** 60 ************** 45 ********* 0
liver *********** 400 ************* 450 ******** 400
brain *********** 8 *************** 0 ********** 0
muscle ********** 1200 ************ 450 ******** 24000
adipose(fat) **** 80 ************** 135,000 **** 40

from Stryer Biochemistry 4th Edition page 771

Look at the chart and find the biggest number. The largest amount of available energy in an average 70 kilogram human is overwhelmingly stored in -fat. For the purpose of this discussion let's think of each of these numbers above as fuel tanks, for our energy needs. When we fill up our cars with gasoline (our old Mercedes B100 biodiesel) we have to have a fuel hose to get the fuel into our gas tank. In order to use that fuel in our gas tanks, we have to have a fuel line leading from the gas tank to the motor in our car. Without these fuel lines, we could not utilize our engine / car.

Enzymatic Induction

Human biochemistry is composed of many different enzyme systems. One such enzyme is phosphofructokinase that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-bisphosphate. As with any biochemical reaction that is dependant on an enzyme system, the more it is used, the more developed it becomes. If there is no need for an enzyme, then the levels in the body will be very low. If there is much demand for an enzyme, then the body will synthesize more of it to meet the demands.

Filling your tank with gas

The fuel line for the human body to fill its energy storage tanks, especially the largest energy storage tank fat, is insulin. Insulin is the hose that energy (gasoline, biodiesel) flows from the storage tank (breakdown products of your recently ingested meals) into your gas tank for future use. Without this fuel line insulin, you will eventually go into a coma (hyperosmolar) that if not treated, can result in less than optimal outcomes.

Using the gas in your tank

When we drive our cars, we use the energy stored in the fuel tanks. In order for us to use that fuel, it must get from the storage tank to the motor. In the human, that fuel line is glucagon. Remember, insulin stores energy, glucagon utilizes that stored energy. Just as insulin stimulates energy storage and the necessary enzyme systems, glucagon stimulates energy utilization and the necessary enzyme systems required to accomplish this.

Life in the Fed State

The problem today is that we have evolved from creatures that did not have consistent daily feedings to our "modern" fast food insanity and the notion that now we need three "square" meals a day plus snacks. What happens to our energy metabolism when we start out putting insulin stimulating foods in our stomach three times a day? When we eat, our biochemistry reacts by secreting insulin, so that we can store all this energy for future needs -most of it going into fat. Long before we have used any of this energy, we are having another meal -lunch. More gas in our tanks, -none used yet. Then comes dinner -more gas into our tank. Snacks -more gas in. We spend our whole day and most of the night in a "fed" or insulin state.

Huge fuel tanks full of fat -everywhere

Because we never allow our body's insulin level to drop enough so that the glucagon level will rise, we never get into a "glucagon" state. Our whole car is now filled mostly with gas. There is hardly any room for a driver in the front seat. Huge fuel tanks full of fat are everywhere we look. Your car is loaded with gas, but you can't drive around the block because you haven't developed the enzymes of energy utilization to establish a fuel line between all these gas tanks full of fat and our motor, which is now also encased in fat. While insulin is the fuel line to fill our energy stores, glucagon is the fuel line to use this stored energy. Without proper stimulation of the glucagon system, our tanks just keep filling up with fat. We never develop the necessary enzymes to use all this energy. You don't have to travel too far to see people totally encased in their stored energy.

Livin' la vida de glucagon

To break this cycle, we need to stop eating for at least a portion of the day, or at least every other day. I don't know how many of you have ever fasted for 24 hours or more, but the feeling is incredible. You get a lot more work done, you don't get lethargic after eating and you start to actually feel thin. I don't recommend fasting more than 24 hours and I am not actually recommending a 24 hour fast. What I am recommending is that during some portion of every day or at least every other day, you refrain from eating anything so that you can get into a glucagon state and begin to induce the necessary enzymes to use all the energy the human body can store.

Summary

Like it or not, three meals a day plus snacks is just not healthy.

To sign up for Dr. Mericle's Newsletter or visit the MericleDiet please click on the link below.

http://www.drmericle.com

DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.

eco-friendly cleaning service Buffalo Grove ..

In The News:

A new phone return scam targets recent buyers with fake carrier calls. Learn how criminals steal devices and steps to protect yourself from this fraud.

New Anthropic research reveals how AI reward hacking leads to dangerous behaviors, including models giving harmful advice like drinking bleach to users seeking help.

The Fox News AI Newsletter gives readers the latest AI technology advancements, covering the challenges and opportunities AI presents.

Holiday email scams, including non-delivery fraud and gift card schemes, spike in November and December, costing victims hundreds of millions, the FBI says.

Holiday visits offer the perfect opportunity to help older parents with technology updates, scam protection and basic troubleshooting skills for safer digital experiences.

Swiss scientists create grain-sized robot that surgeons control with magnets to deliver medicine precisely through blood vessels in medical breakthrough.

Researchers exploited WhatsApp's API vulnerability to scrape 3.5 billion phone numbers. Learn how this massive data breach happened and protect yourself.

Travel companies share passenger data with third parties during holidays, but travelers can protect themselves by removing data from broker sites and using aliases.

Xpeng's humanoid robot moves so realistically that crowds believed it was fake, marking a major advancement in robotics technology ahead of 2026 commercial launch.

Researchers discover phishing scam using invisible characters to evade email security, with protection tips including password managers and two-factor authentication.

iPhone and Android users can reduce battery drain and data usage by restricting Background App Refresh to Wi-Fi connections instead of mobile networks.

Scammers nearly stole an Apple account by exploiting the support system with authentic-looking tickets and phone calls, users can protect themselves with safety steps.

FoloToy restored sales of its AI teddy bear Kumma after a weeklong suspension following safety group findings of risky and inappropriate responses to children.

Threat intelligence firm Synthient uncovers one of the largest password exposures ever, prompting immediate security recommendations.

Viral video shared by Elon Musk shows Tesla's Optimus humanoid robots performing tasks from cooking to construction, garnering over 58.5 million views on social media.

Chinese hackers used Anthropic's Claude AI to launch autonomous cyberattacks on 30 organizations worldwide, marking a major shift in cybersecurity threats.

Apple's new Sleep Score feature gives you a rating for your nightly rest quality. Learn how to set it up on your Apple Watch and iPhone today.

Essential phone settings to enable before losing your device, including Find My network, location services and security features for iPhone and Android.

The Fox News AI Newsletter gives readers the latest AI technology advancements, covering the challenges and opportunities AI presents.

Cybersecurity research shows weak passwords remain a major threat, with simple patterns and number sequences putting millions of accounts at risk.

New Android malware BankBot YNRK silences phones, steals banking data and drains crypto wallets automatically. Learn how this advanced threat works.

FDA approves first human trial for Paradromics' brain-computer interface that could restore speech for paralyzed patients through neural technology.

New phishing platform QRR targets Microsoft 365 users across 1,000 domains in 90 countries. Learn how to spot fake login pages and protect your accounts.

OpenTable now uses AI to track your dining habits and share insights with restaurants. Learn what data they collect and how to protect your privacy.

Google's discontinued Nest thermostats still secretly upload home data to company servers despite losing smart features, raising serious privacy concerns.